其中最主要的一个原因是维生素D参与到多种神经递质的合成。 合成血清素(Sertotonin)需要色氨酸羟化酶(tryptophan hydroxylase),而色氨酸羟化酶的基因表达需要维生素D的参与;而酪氨酸羟化酶(tyrosine hydroxylase)是儿茶酚胺(catecholamines)的限速酶,而酪氨酸羟化酶的表达也需要维生素D的差异,所以维生素D影响着中枢神经的多种神经递质的数量包括血清素、肾上腺素、去甲肾上腺素和多巴胺等。[1] [2]
参考资料
[1] Cui X, Pertile R, Liu P, et al.(2015), Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator. Neuroscience 2015;304:90–100.
[2] Kaneko I, Sabir MS, Dussik CM, et al.(2015), 1,25-Dihydroxy vitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D. Faseb J 2015;29:4023–35.